Allen and Hines recognised lipedema in 1940. Lipedema was not recognised as a disease by WHO until 2019. Lipedema has been treated by physicians depending on the presentation and stage of the disease. This is because lipedema is still not taught in most medical schools across the globe. There are very few professionals who are working on lipedema and there is little ongoing research to find out the causes and the solutions to manage lipedema. It has been found that there is a polygenic predilection and that there are 14 genes implicated with lipedema till date. Lipedema usually starts around puberty, pregnancy or menopause, or can be aggravated during those periods which also gives an indication that there is a hormonal effect. Though the actual incidence or prevalence of lipedema is not known, estimates are that nearly 11% of women are affected globally in some form and stage of the disease.